Decision on Optimal Combinatorial Therapies in IMIDS using Systems Approaches

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Why DoCTIS

The DoCTIS project has been designed to address this important health problem in IMIDs. To do so, we will identify new combinations of existing drugs that potentiate the effect of each other. This combinatorial effect will have many beneficial aspects for IMID patients: it will lower the disease activity down to remission (i.e. free of symptoms), it will allow to reduce drug dosage (and, therefore, reduce the risk of toxicity) and, finally, it will reduce the probability of becoming resistant to the therapy.

The DoCTIS project

DoCTIS is a multicentric project involving diverse basic, applied and clinical research centres from Spain, Sweden, Italy, Germany, UK and USA, and is aimed at improving treatment efficacy in six Immune-Mediated Inflammatory Diseases (IMIDs). These IMIDs encompass Crohn’s disease, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, psoriasis and psoriatic arthritis. Through the generation of high volumes of data using modern high-throughput technologies on samples from well-characterized IMID patients, and the use of advanced systems biology analytical approaches, we aim to identify therapeutic combinations that are much more efficacious and safer than the current single-drug approaches.

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About DoCTIS

DoCTIS is the acronym for the EU-funded project entitled “Decision on Combinatorial Therapies in Immune-Mediated diseases using Systems approaches”. DoCTIS is a multicentric project involving diverse basic, applied and clinical research centres from Spain, Sweden, Italy, Germany, UK and USA aimed at improving treatment efficacy in six Immune-Mediated Inflammatory Diseases (IMIDs), encompassing: Crohn’s disease, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, psoriasis and psoriatic arthritis.

  • Project Overview

    DoCTIS is an EU-funded translational project aimed at addressing the urgent need to discover effective therapeutic strategies for immune-mediated inflammatory diseases.

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  • Work Packages

    The DoCTIS project is structured in nine different work packages, involving animal model, patient, systems biology and clinical evaluation stages.

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  • Partners

    Biomedical research partners from five different European countries as well as from the United States of America are collaborating toward this.

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The DoCTIS project has received funding from the European Union’s H2020 reearch and innovation program under grant agreement 848028.